Author: Emma Elsdon, junior
This summer, I had the privilege of working as a visiting researcher in Dr. Juan Del Valle’s lab at the University of Notre Dame in South Bend, IN. The Del Valle lab is part of the Notre Dame Department of Chemistry and Biochemistry, and a major focus of the lab is peptide and protein mimics. My specific project concerns an interaction between two proteins, Tau and Fyn kinase, that is associated with Alzheimer’s disease. I am working to develop peptides, or small protein fragments, that inhibit the Tau-Fyn interaction and therefore slow the progression of Alzheimer’s. This summer I have focused primarily on creating an enzyme-linked immunosorbent assay (ELISA) that will be able to test whether or not the peptides I make are effective inhibitors. I will be using this assay back at Fordham as I continue my project in Dr. Nicholas Sawyer’s lab, which will ultimately provide a central focus for my senior Honors thesis.
The Del Valle lab group is composed of mostly graduate students and a few undergraduate students. Because Fordham does not have a chemistry graduate program, working among graduate students and having one of them as a mentor was a novel experience for me. I gained exposure to several new laboratory techniques, while increasing my competency as a scientist and helping with other Tau-related projects. I received valuable guidance as I navigated the numerous roadblocks of assay development, as well as academic and career advice from colleagues currently on the PhD track I hope to pursue. I also exercised independence when it came to the progression of my project, taking responsibility for experiment workflow and data analysis.
In this position, I have met fascinating people from around the world and become immersed in the campus culture of Notre Dame. I spent the summer surrounded by the cutting edge of scientific research and had the opportunity to envision my future life as a chemistry graduate student. I am beyond grateful to the Honors Program for making it possible for me to engage with the Del Valle lab and dive into my research that ultimately seeks to treat Alzheimer’s disease.